P41 Liver disease-specific gene expression profile in hepatocellular carcinoma

Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Our objective was to study nonalcoholic fatty liver disease (NAFLD) as a relevant risk factor associated with hepatocellular carcinoma (HCC) in patients with and without cirrhosis. HCC is a common cancer worldwide that predominantly involves patients with hepatic cirrhosis. HCC has recently been linked to NAFLD, the hepatic manifestation of obesity and related metabolic disorders. This associat...

plasma osteopontin level in chronic liver disease and hepatocellular carcinoma

conclusions plasma opn is comparable to afp as a diagnostic marker and is related to the severity of liver involvement in hcc patients. plasma opn is of diagnostic potential value in nafld. background osteopontin (opn) is a secreted glycoprotein and is frequently associated with various tumors. objectives we sought to investigate the clinical usefulness of the level of plasma opn, compared to α...

Hepatocellular Carcinoma in Sheep

Gene expression of erythropoietin in hepatocellular carcinoma.

A 68-year-old man with hepatocellular carcinoma complicated by erythrocytosis showed an increased plasma level of immunoreactive erythropoietin (EPO). Northern blot analysis and RT-PCR (reverse transcriptase and polymerase chain reaction) of EPO mRNA extracted from a surgical specimen indicated high expression of EPO mRNA in the tumor tissue. Histological and immunocytochemical examination show...

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) incidence is increasing worldwide in recent years. Most HCC cases develop in the presence of advanced chronic liver disease related to chronic hepatitis C virus (HCV) infection, chronic hepatitis B (HBV) infection, and alcohol abuse. Approximately 15-50% of HCC cases are classified as idiopathic, suggesting that other risk factors are responsible for its rising in...